2-Furoyl-LIGRLO-amide
2-Furoyl-LIGRLO-amide is a potent, selective protease-activated receptor 2 (PAR2) agonist where PAR-2 activation is associated with increases in cAMP and intracellular Ca(2+). Immunoblot analysis revealed, increases in phosphorylation of epidermal growth factor (EGF) receptor (EGFR) tyrosine kinase, Src, Pyk2, cRaf, and ERK1/2 in response to PAR-2 activation.
| Catalog Number | R1835 |
| Alternative Name(s) | 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt, 2-fAP, 2-Fly |
| Molecular Formula | C36H63N11O8 |
| CAS# | 729589-58-6 |
| Purity | >95% |
| Inchi | InChI=1S/C36H63N11O8/c1-7-22(6)29(47-33(52)26(18-21(4)5)46-34(53)27-13-10-16-55-27)35(54)42-19-28(48)43-24(12-9-15-41-36(39)40)31(50)45-25(17-20(2)3)32(51)44-23(30(38)49)11-8-14-37/h10,13,16,20-26,29H,7-9,11-12,14-15,17-19,37H2,1-6H3,(H2,38,49)(H,42,54)(H,43,48)(H,44,51)(H,45,50)(H,46,53)(H,47,52)(H4,39,40,41)/t22-,23-,24-,25-,26-,29-/m0/s1 |
| Inchi Key | OSKIRYSKGDEIOG-WTWMNNMUSA-N |
| SMILES | CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN)C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)C1=CC=CO1 |
| Size | Inquiry |
| Supplier Page | https://www.creative-peptides.com/product/2-furoyl-ligrlo-amide-item-r1835-39370.html |