PMX 53
PMX-53 is an effective c5a receptor antagonist (ic50 = 20 nm), which inhibits C5a-induced hypernociception in rats, inhibits lung metastasis in a mouse breast cancer model and reduces atherosclerotic lesions in a mouse model of atherosclerosis. It also is an agonist for Mas-related gene 2 (MrgX2) in human mast cells.
| Catalog Number | R0880 |
| Alternative Name(s) | PMX 53,Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg |
| Molecular Formula | C47H65N11O7 |
| CAS# | 219639-75-5 |
| Purity | >98% |
| Inchi | InChI=1S/C47H65N11O7/c1-29(59)53-37(25-30-13-4-2-5-14-30)42(61)55-36-20-11-22-50-41(60)35(19-10-23-51-47(48)49)54-44(63)39(27-32-28-52-34-18-9-8-17-33(32)34)56-43(62)38(26-31-15-6-3-7-16-31)57-45(64)40-21-12-24-58(40)46(36)65/h2,4-5,8-9,13-14,17-18,28,31,35-40,52H,3,6-7,10-12,15-16,19-27H2,1H3,(H,50,60)(H,53,59)(H,54,63)(H,55,61)(H,56,62)(H,57,64)(H4,48,49,51) |
| Inchi Key | YOKBGCTZYPOSQM-UHFFFAOYSA-N |
| Size | Inquiry |
| Supplier Page | https://www.creative-peptides.com/product/pmx-53-item-r0880-34682.html |