CSP-2, Competence-Stimulating Peptide-2 peptide with sequence of EMRISRIILDFLFLRKK are genetic transformation in streptococcus pneumoniae, Streptococcus mitis and Streptococcus oralis is regulated by secreted peptide pheromones named the competence-stimulating peptide (CSP). Different strains and species of these bacteria produce CSP with different primary sequence. Other CSP sequence are: CSP-1 (EMRLSKFFRDFILQRKK), CSP-153 (DKRLPYFFKHLFSNRTK), CSP-612