PMX 205
Potent C5a receptor peptide antagonist (IC50 = 31 nM). Ameliorates experimentally-induced colon inflammation in mice. Reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer’s Disease. Orally active and brain penetrant.
| Catalog Number | 10-101-154 |
| Alternative Name(s) | PMX-205,Hydrocinnamate |
| Research Area | PMX-205 is a potent antagonist of C5a receptor. It is used as anti-inflammatory drug. |
| Molecular Formula | C45H62N10O6 |
| CAS# | 514814-49-4 |
| Purity | >98% |
| Inchi | InChI=1S/C45H62N10O6/c46-45(47)49-24-9-18-34-40(57)48-23-10-19-35(51-39(56)22-21-29-12-3-1-4-13-29)44(61)55-25-11-20-38(55)43(60)54-36(26-30-14-5-2-6-15-30)41(58)53-37(42(59)52-34)27-31-28-50-33-17-8-7-16-32(31)33/h1,3-4,7-8,12-13,16-17,28,30,34-38,50H,2,5-6,9-11,14-15,18-27H2,(H,48,57)(H,51,56)(H,52,59)(H,53,58)(H,54,60)(H4,46,47,49)/t34-,35-,36+,37-,38-/m0/s1 |
| Inchi Key | VATFHFJULBPYLM-ILOBPARPSA-N |
| SMILES | C1CCC(CC1)C[C@@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)NCCC[C@@H](C(=O)N3CCC[C@H]3C(=O)N2)NC(=O)CCC4=CC=CC=C4)CCCN=C(N)N)CC5=CNC6=CC=CC=C65 |
| Size | Inquiry |
| Supplier Page | https://www.creative-peptides.com/product/pmx-205-item-10-101-154-33641.html |