Atovaquone
Atovaquone is a broad-spectrum antiprotozoal agent that is active against Plasmodium, Toxoplasma, and Babesia, among other protozoa. It inhibits complex III activity on dihydroorotate in isolated P. falciparum and P. yoelii mitochondria more potently than in rat liver mitochondria and depolarizes the mitochondrial membrane in P. yoelii-infected mouse erythrocytes. Atovaquone also inhibits transport mediated by human breast cancer resistance protein (BCRP) and P-glycoprotein in membrane vesicles.
| Trivial name | Atovaquone (RE1007) |
| Catalog Number | RE1007 |
| Alternative Name(s) | BW 556C-80; Mepron; BW 566C; trans-2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione |
| Research Area | Other/Reagents |
| Molecular Formula | C₂₂H₁₉ClO₃ |
| Inchi | InChI=1S/C22H19ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)17-3-1-2-4-18(17)21(25)22(19)26/h1-4,9-13,15,24H,5-8H2 |
| Size | 10mg |
| Supplier Page | https://www.mitochondriasci.com/atovaquone-item-578.html |
| Additional Information | Appearance:Orange solid |