CBL0137 HCl
CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-κB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).
| Trivial name | CBLC137 HCl, Curaxin 137 HCl |
| Catalog Number | S8483 |
| Molecular Formula | C21H24N2O2.HCl |
| CAS# | 1197397-89-9 |
| Inchi | InChI=1S/C21H24N2O2.ClH/c1-13(2)22-9-10-23-20-7-5-16(14(3)24)11-18(20)19-12-17(15(4)25)6-8-21(19)23;/h5-8,11-13,22H,9-10H2,1-4H3;1H |
| Inchi Key | IXRKBBVMDMKAEB-UHFFFAOYSA-N |
| SMILES | CC(C)NCCN1C2=C(C=C(C=C2)C(=O)C)C3=C1C=CC(=C3)C(=O)C.Cl |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/cbl0137-cbl-0137.html |
| Additional Information | https://file.selleck.cn/downloads/struct/cbl0137-cbl-0137-chemical-structure-s8483.gif |