SAR405
SAR405 is a low-molecular-mass kinase inhibitor of PIK3C3/Vps34 (KD 1.5 nM) showing high selectivity and not be active up to 10 μM on class I and class II PI3Ks as well as on mTOR. SAR405 prevents autophagy and synergizes with MTOR (mechanistic target of rapamycin) inhibition in tumor cells.
| Trivial name | N/A |
| Catalog Number | S7682 |
| Molecular Formula | C19H21ClF3N5O2 |
| CAS# | 1523406-39-4 |
| Inchi | InChI=1S/C19H21ClF3N5O2/c1-12-11-30-5-4-26(12)16-7-17(29)27-3-2-15(19(21,22)23)28(18(27)25-16)10-13-6-14(20)9-24-8-13/h6-9,12,15H,2-5,10-11H2,1H3/t12-,15+/m1/s1 |
| Inchi Key | SPDQRCUBFSRAFI-DOMZBBRYSA-N |
| SMILES | CC1COCCN1C2=CC(=O)N3CCC(N(C3=N2)CC4=CC(=CN=C4)Cl)C(F)(F)F |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/sar405.html |
| Additional Information | https://file.selleck.cn/downloads/struct/sar405-chemical-structure-S7682.gif |