Binimetinib (MEK162)

Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Binimetinib induces G1 cell cycle arrest and apoptosis in human NSCLC cell lines and induces autophagy. Phase 3.

Price Not Available 10mM/1mL Binimetinib (MEK162) Supplier Page

Trivial name	ARRY-162,ARRY-438162
Catalog Number	S7007
Molecular Formula	C17H15BrF2N4O3
CAS#	606143-89-9
Inchi	InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
Inchi Key	ACWZRVQXLIRSDF-UHFFFAOYSA-N
SMILES	CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/mek162.html
Additional Information	https://file.selleck.cn/downloads/struct/MEK162-chemical-structure-s7007.gif