Wortmannin
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM in a cell-free assay, with little selectivity within the PI3K family. Wortmannin blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM in cell-free assays. Wortmannin also inhibits PLK1 activity.
| Trivial name | KY 12420, SL-2052, BRN 0067676, NSC 627609 |
| Catalog Number | S2758 |
| Molecular Formula | C23H24O8 |
| CAS# | 19545-26-7 |
| Inchi | InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1 |
| Inchi Key | QDLHCMPXEPAAMD-QAIWCSMKSA-N |
| SMILES | CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/wortmannin.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Wortmannin-chemical-structure-s2758.gif |