Dovitinib (TKI258) Lactate monohydrate
Dovitinib (TKI258) Lactate monohydrate is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.
| Trivial name | CHIR258 |
| Catalog Number | S7765 |
| Molecular Formula | C24H29FN6O5 |
| CAS# | 915769-50-5 |
| Inchi | InChI=1S/C21H21FN6O.C3H6O3/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29;1-2(4)3(5)6/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29);2,4H,1H3,(H,5,6) |
| Inchi Key | ZRHDKBOBHHFLBW-UHFFFAOYSA-N |
| SMILES | CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N.O |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/dovitinib-tki258-lactate.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s7765-dovitinib-tki258-lactate-chemical-structure.gif |