Piperlongumine
Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells.
| Trivial name | PPLGM, Piplartine |
| Catalog Number | S7551 |
| Molecular Formula | C17H19NO5 |
| CAS# | 20069-09-4 |
| Inchi | InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+ |
| Inchi Key | VABYUUZNAVQNPG-BQYQJAHWSA-N |
| SMILES | COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/piperlongumine.html |
| Additional Information | https://file.selleck.cn/downloads/struct/piperlongumine-chemical-structure-s7551.gif |