Poziotinib
Poziotinib is an irreversible pan-HER inhibitor with IC50 of 3.2 nM, 5.3 nM and 23.5 nM for HER1, HER2, and HER4, respectively. Poziotinib also induces apoptosis and G1 cell cycle arrest. Phase 2.
| Trivial name | HM781-36B, NOV120101 |
| Catalog Number | S7358 |
| Molecular Formula | C₂₃H₂₁Cl₂FN₄O₃ |
| CAS# | 1092364-38-9 |
| Inchi | InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29) |
| Inchi Key | LPFWVDIFUFFKJU-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/poziotinib-hm781-36b.html |
| Additional Information | https://file.selleck.cn/downloads/struct/poziotinib-hm781-36b-nov120101-chemical-structure-s7358.gif |