EPZ004777
EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM in a cell-free assay and demonstrates >1,200-fold selectivity for DOT1L over all other tested PMTs. EPZ004777 induces apoptosis.
| Trivial name | N/A |
| Catalog Number | S7353 |
| Molecular Formula | C28H41N7O4 |
| CAS# | 1338466-77-5 |
| Inchi | InChI=1S/C28H41N7O4/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31 ,32)(H2,30,33,38)/t21-,22-,23-,26-/m1/s1 |
| Inchi Key | WXRGFPHDRFQODR-ICLZECGLSA-N |
| SMILES | CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2C(C(C(O2)N3C=CC4=C(N=CN=C43)N)O)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/epz004777.html |
| Additional Information | https://file.selleck.cn/downloads/struct/EPZ004777-chemical-structure-s7032.gif |