GSK923295
GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. GSK923295 induces post-mitotic apoptosis. Phase 1.
| Trivial name | N/A |
| Catalog Number | S7090 |
| Molecular Formula | C32H38ClN5O4 |
| CAS# | 1088965-37-0 |
| Inchi | InChI=1S/C32H38ClN5O4/c1-20(2)42-29-13-12-24(16-27(29)33)32(41)35-25(17-34-30(40)19-37(4)5)15-22-8-10-23(11-9-22)28-18-38-14-6-7-26(21(3)39)31(38)36-28/h6-14,16,18,20-21,25,39H,15,17,19H2,1-5H3,(H,34, 40)(H,35,41)/t21-,25-/m0/s1 |
| Inchi Key | WHMXDBPHBVLYRC-OFVILXPXSA-N |
| SMILES | CC(C)OC1=C(C=C(C=C1)C(=O)NC(CC2=CC=C(C=C2)C3=CN4C=CC=C(C4=N3)C(C)O)CNC(=O)CN(C)C)Cl |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/gsk923295.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GSK923295-chemical-structure-s7090.gif |