Triptolide
Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway.
| Trivial name | PG490, NSC 163062 |
| Catalog Number | S3604 |
| Molecular Formula | C20H24O6 |
| CAS# | 38748-32-2 |
| Inchi | InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1 |
| Inchi Key | DFBIRQPKNDILPW-CIVMWXNOSA-N |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/triptolide.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Triptolide-chemical-structure-s3604.jpg |