Purmorphamine
Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM. Purmorphamine can reduce both basal and induced autophagy.
| Trivial name | Shh Signaling Antagonist VI |
| Catalog Number | S3042 |
| Molecular Formula | C14H8O4 |
| CAS# | 483367-10-8 |
| Inchi | InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H,1H3 |
| Inchi Key | DPHUWDIXHNQOSY-UHFFFAOYSA-N |
| SMILES | CC(=O)C1=CC2=C(O1)C(=O)C3=CC=CC=C3C2=O |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/purmorphamine.html |
| Additional Information | https://file.selleck.cn/downloads/struct/purmorphamine-chemical-structure-s3042.jpg |