Pazopanib
Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms/CSF1R with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces cathepsin B activation and autophagy.
| Trivial name | GW786034 |
| Catalog Number | S3012 |
| Molecular Formula | C19H36O5 |
| CAS# | 444731-52-6 |
| Inchi | InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24) |
| Inchi Key | HYHMLYSLQUKXKP-UHFFFAOYSA-N |
| SMILES | CC(C)(CCCCCC(CCCCCC(C)(C)C(=O)O)O)C(=O)O |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/pazopanib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Pazopanib-chemical-structure-s3012.gif |