Laduviglusib (CHIR-99021) HCl

Laduviglusib (CHIR-99021; CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins.

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Trivial name	CT99021 HCl
Catalog Number	S2924
Molecular Formula	C21H24N4O3
CAS#	1797989-42-4
Inchi	InChI=1S/C21H24N4O3/c1-23-17-12-15(22-20(26)14-8-4-5-9-19(14)28-3)16(25-10-6-7-11-25)13-18(17)24(2)21(23)27/h4-5,8-9,12-13H,6-7,10-11H2,1-3H3,(H,22,26)
Inchi Key	QCIJLRJBZDBVDB-UHFFFAOYSA-N
SMILES	CN1C2=C(C=C(C(=C2)NC(=O)C3=CC=CC=C3OC)N4CCCC4)N(C1=O)C
Size	25mg
Supplier Page	http://www.selleckchem.com/products/chir-99021-ct99021-hcl.html
Additional Information	https://file.selleck.cn/downloads/struct/CHIR-99021-CT99021-hcl-chemical-structure-s2924.gif