Laduviglusib (CHIR-99021) HCl

Laduviglusib (CHIR-99021; CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins.

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Trivial name	CT99021 HCl
Catalog Number	S2924
Molecular Formula	C20H24N10O13 P2·xNa+
CAS#	1797989-42-4
SMILES	C1C2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)O)OP(=O)(OCC5C(C(C(O5)N6C=NC7=C(N=CN=C76)N)O)OP(=O)(O1)O)O
Size	5mg
Supplier Page	http://www.selleckchem.com/products/chir-99021-ct99021-hcl.html
Additional Information	https://file.selleck.cn/downloads/struct/CHIR-99021-CT99021-hcl-chemical-structure-s2924.gif