IOX2
IOX2 (JICL38) is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.
| Trivial name | JICL38 |
| Catalog Number | S2919 |
| Molecular Formula | C19H16N2O5 |
| CAS# | 931398-72-0 |
| Inchi | InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23) |
| Inchi Key | CAOSCCRYLYQBES-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/iox2.html |
| Additional Information | https://file.selleck.cn/downloads/struct/IOX2-chemical-structure-s2919.jpg |