IOX2
IOX2 (JICL38) is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.
| Trivial name | JICL38 |
| Catalog Number | S2919 |
| Molecular Formula | C26H20ClN3O5 |
| CAS# | 931398-72-0 |
| Inchi | InChI=1S/C26H20ClN3O5/c1-34-18-6-3-5-17(13-18)30-25(32)23-20(28-26(30)33)14-22(27)29(23)16-11-9-15(10-12-16)19-7-4-8-21(35-2)24(19)31/h3-14,31H,1-2H3,(H,28,33) |
| Inchi Key | KURYSXLJGKKDHT-UHFFFAOYSA-N |
| SMILES | COC1=CC=CC(=C1)N2C(=O)C3=C(C=C(N3C4=CC=C(C=C4)C5=C(C(=CC=C5)OC)O)Cl)NC2=O |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/iox2.html |
| Additional Information | https://file.selleck.cn/downloads/struct/IOX2-chemical-structure-s2919.jpg |