PF-477736
PF-477736 (PF-736, PF-00477736) is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2.
| Trivial name | PF-736, PF-00477736 |
| Catalog Number | S2904 |
| Molecular Formula | C21H14N2Na2O9S2 |
| CAS# | 952021-60-2 |
| Inchi | InChI=1S/C21H16N2O9S2.2Na/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32;;/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32);;/q;2*+1/p-2 |
| Inchi Key | MOUNHKKCIGVIDI-UHFFFAOYSA-L |
| SMILES | C1=CC2=C(C=C(C=C2C=C1NC(=O)NC3=CC4=CC(=CC(=C4C=C3)O)S(=O)(=O)[O-])S(=O)(=O)[O-])O.[Na+].[Na+] |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/pf-477736.html |
| Additional Information | https://file.selleck.cn/downloads/struct/pf-477736-chemical-structure-s2904.gif |