PF-562271
PF-562271 (PF-00562271) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
| Trivial name | PF-00562271 |
| Catalog Number | S2890 |
| Molecular Formula | C21H20F3N7O3S |
| CAS# | 717907-75-0 |
| Inchi | InChI=1S/C21H20F3N7O3S/c1-31(35(2,33)34)19-12(4-3-7-25-19)10-26-18-15(21(22,23)24)11-27-20(30-18)28-14-5-6-16-13(8-14)9-17(32)29-16/h3-8,11H,9-10H2,1-2H3,(H,29,32)(H2,26,27,28,30) |
| Inchi Key | MZDKLVOWGIOKTN-UHFFFAOYSA-N |
| SMILES | CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/pf-562271.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PF-562271-chemical-structure-s2890.jpg |