IKK-16
IKK-16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively. IKK-16 also inhibits LRRK2 Ser935 phosphorylation in cells and LRRK2 kinase activity in vitro with IC50 of 50 nM.
| Trivial name | IKK Inhibitor VII |
| Catalog Number | S2882 |
| Molecular Formula | C28H29N5OS |
| CAS# | 873225-46-8 |
| Inchi | InChI=1S/C28H29N5OS/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31) |
| Inchi Key | BWZJBXAPRCVCKQ-UHFFFAOYSA-N |
| SMILES | C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/ikk-16.html |
| Additional Information | https://file.selleck.cn/downloads/struct/IKK-16-chemical-structure-s2882.jpg |