Semaxanib (SU5416)
Semaxanib (SU5416, semaxinib) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR. Phase 3.Semaxanib (SU5416) can be used to induce animal models of chronic intermittent hypoxia.
Trivial name | semaxinib |
Catalog Number | S2845 |
Molecular Formula | C25H28ClNO2 |
CAS# | 204005-46-9 |
Inchi | InChI=1S/C25H27NO2.ClH/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2;/h4-16,26-27H,3,17-18H2,1-2H3;1H/b25-24-; |
Inchi Key | RPFIMPDXTABYCN-BJFQDICYSA-N |
SMILES | CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCNC)C3=CC=CC=C3.Cl |
Size | 50mg |
Supplier Page | http://www.selleckchem.com/products/semaxanib-su5416.html |
Additional Information | https://file.selleck.cn/downloads/struct/Semaxanib-chemical-structure-s2845.gif |