BI-D1870
BI-D1870 is an ATP-competitive inhibitor of S6 ribosome for RSK1/2/3/4 with IC50 of 31 nM/24 nM/18 nM/15 nM in cell-free assays, respectively; 10- to 100-fold selectivity for RSK than MST2, GSK-3β, MARK3, CK1 and Aurora B. BI-D1870 exhibits anticancer attributes including the generation of reactive oxygen species (ROS) and increases in endoplasmic reticulum (ER) stress and autophagy.
| Trivial name | N/A |
| Catalog Number | S2843 |
| Molecular Formula | C19H23F2N5O2 |
| CAS# | 501437-28-1 |
| Inchi | InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24) |
| Inchi Key | DTEKTGDVSARYDS-UHFFFAOYSA-N |
| SMILES | CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/bi-d1870.html |
| Additional Information | https://file.selleck.cn/downloads/struct/BI-D1870-chemical-structure-s2843.gif |