Alpelisib (BYL719)
Alpelisib (BYL719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.
Trivial name | N/A |
Catalog Number | S2814 |
Molecular Formula | C26H23F4N9O |
CAS# | 1217486-61-7 |
Inchi | InChI=1S/C26H23F4N9O/c27-20-18(1-7-32-22(20)26(28,29)30)24(40)37-9-3-17(4-10-37)38-13-25(14-38,5-6-31)39-12-16(11-36-39)21-19-2-8-33-23(19)35-15-34-21/h1-2,7-8,11-12,15,17H,3-5,9-10,13-14H2,(H,33,34,3 5) |
Inchi Key | KTBSXLIQKWEBRB-UHFFFAOYSA-N |
SMILES | C1CN(CCC1N2CC(C2)(CC#N)N3C=C(C=N3)C4=C5C=CNC5=NC=N4)C(=O)C6=C(C(=NC=C6)C(F)(F)F)F |
Size | 5mg |
Supplier Page | http://www.selleckchem.com/products/byl719.html |
Additional Information | https://file.selleck.cn/downloads/struct/BYL-719-chemical-structure-s2814.gif |