(R)-(-)-Gossypol (AT-101) acetic acid

(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.

Price Not Available 10mM/1mL (R)-(-)-Gossypol (AT-101) acetic acid Supplier Page

Catalog Number	S2812
Molecular Formula	C26H23F4N9O
CAS#	866541-93-7
Inchi	InChI=1S/C26H23F4N9O/c27-20-18(1-7-32-22(20)26(28,29)30)24(40)37-9-3-17(4-10-37)38-13-25(14-38,5-6-31)39-12-16(11-36-39)21-19-2-8-33-23(19)35-15-34-21/h1-2,7-8,11-12,15,17H,3-5,9-10,13-14H2,(H,33,34,3 5)
Inchi Key	KTBSXLIQKWEBRB-UHFFFAOYSA-N
SMILES	C1CN(CCC1N2CC(C2)(CC#N)N3C=C(C=N3)C4=C5C=CNC5=NC=N4)C(=O)C6=C(C(=NC=C6)C(F)(F)F)F
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/at101-acetic-acid.html
Additional Information	https://file.selleck.cn/downloads/struct/AT101-chemical-structure-s2812.gif