Sapanisertib (MLN0128)
Sapanisertib (MLN0128, INK 128, TAK-228) is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin). Phase 1.
| Trivial name | INK 128,TAK-228 |
| Catalog Number | S2811 |
| Molecular Formula | C17H21N7O4 |
| CAS# | 1224844-38-5 |
| Inchi | InChI=1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21) |
| Inchi Key | MSSXBKQZZINCRI-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=NC(=NC(=N2)NC3=CC=C(C=C3)[N+](=O)[O-])N4CCOCC4 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/ink128.html |
| Additional Information | https://file.selleck.cn/downloads/struct/INK-128-chemical-structure-s2811.gif |