Dabrafenib
Dabrafenib is a mutant BRAFV600E specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
| Trivial name | GSK2118436, GSK2118436A |
| Catalog Number | S2807 |
| Molecular Formula | C20H23N2O5S.Na |
| CAS# | 1195765-45-7 |
| Inchi | InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1 |
| Inchi Key | LFQQNXFKPNZRFT-UHFFFAOYSA-M |
| SMILES | CC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+] |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/dabrafenib-gsk2118436.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GSK2118436-chemical-structure-s2807.gif |