Dabrafenib
Dabrafenib is a mutant BRAFV600E specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
| Trivial name | GSK2118436, GSK2118436A |
| Catalog Number | S2807 |
| Molecular Formula | C16H18Cl3N5O2 |
| CAS# | 1195765-45-7 |
| Inchi | InChI=1S/C16H17Cl2N5O2.ClH/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9;/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24);1H |
| Inchi Key | PAOFPNGYBWGKCO-UHFFFAOYSA-N |
| SMILES | C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl.Cl |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/dabrafenib-gsk2118436.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GSK2118436-chemical-structure-s2807.gif |