LY364947
LY364947 (HTS 466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM in a cell-free assay, shows 7-fold selectivity over TGFβR-II.
| Trivial name | HTS 466284 |
| Catalog Number | S2805 |
| Molecular Formula | C35H51N5O4·HCl |
| CAS# | 396129-53-6 |
| Inchi | InChI=1S/C35H51N5O4.ClH/c1-7-40(30-12-10-29(11-13-30)38(5)15-18-43-6)33-23-28(9-8-14-39-16-19-44-20-17-39)22-31(27(33)4)34(41)36-24-32-25(2)21-26(3)37-35(32)42;/h21-23,29-30H,7,10-20,24H2,1-6H3,(H,36, 41)(H,37,42);1H/t29-,30-; |
| Inchi Key | LHRBDVKQGXCMQN-FVPKQRSSSA-N |
| SMILES | CCN(C1CCC(CC1)N(C)CCOC)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C#CCN4CCOCC4.Cl |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/ly364947.html |
| Additional Information | https://file.selleck.cn/downloads/struct/LY364947-chemical-structure-s2805.gif |