TAK-285
TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. Phase 1.
| Trivial name | N/A |
| Catalog Number | S2784 |
| Molecular Formula | C26H25ClF3N5O3 |
| CAS# | 871026-44-7 |
| Inchi | InChI=1S/C26H25ClF3N5O3/c1-25(2,37)14-22(36)31-9-11-35-10-8-20-23(35)24(33-15-32-20)34-17-6-7-21(19(27)13-17)38-18-5-3-4-16(12-18)26(28,29)30/h3-8,10,12-13,15,37H,9,11,14H2,1-2H3,(H,31,36)(H,32,33,34) |
| Inchi Key | ZYQXEVJIFYIBHZ-UHFFFAOYSA-N |
| SMILES | CC(C)(CC(=O)NCCN1C=CC2=C1C(=NC=N2)NC3=CC(=C(C=C3)OC4=CC=CC(=C4)C(F)(F)F)Cl)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/tak-285.html |
| Additional Information | https://file.selleck.cn/downloads/struct/TAK-285-chemical-structure-s2784.gif |