PF-5274857
PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.
| Trivial name | N/A |
| Catalog Number | S2777 |
| Molecular Formula | C28H29Cl2N3OS |
| CAS# | 1373615-35-0 |
| Inchi | InChI=1S/C28H28ClN3OS.ClH/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20;/h2-8,13-17,22-23,30H,9-12,18H2,1H3;1H/t22-,23?; |
| Inchi Key | CRWTYWYPPITOOZ-XFNHMIAXSA-N |
| SMILES | CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl.Cl |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/pf-5274857.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PF-5274857-chemical-structure-s2777.gif |