MK-5108
MK-5108 is a highly selective Aurora A inhibitor with IC50 of 0.064 nM in a cell-free assay and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity. MK-5108 (VX-689) induces autophagy. Phase 1.
| Trivial name | VX-689 |
| Catalog Number | S2770 |
| Molecular Formula | C26H27F4N3O7 |
| CAS# | 1010085-13-8 |
| Inchi | InChI=1S/C26H27F4N3O7/c1-12(31-24(38)25(39)32-16-8-6-5-7-13(16)26(2,3)4)23(37)33-17(10-19(35)36)18(34)11-40-22-20(29)14(27)9-15(28)21(22)30/h5-9,12,17H,10-11H2,1-4H3,(H,31,38)(H,32,39)(H,33,37)(H,35,3 6)/t12-,17-/m0/s1 |
| Inchi Key | SCVHJVCATBPIHN-SJCJKPOMSA-N |
| SMILES | CC(C(=O)NC(CC(=O)O)C(=O)COC1=C(C(=CC(=C1F)F)F)F)NC(=O)C(=O)NC2=CC=CC=C2C(C)(C)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/mk-5108-vx-689.html |
| Additional Information | https://file.selleck.cn/downloads/struct/MK-5108-chemical-structure-s2770.gif |