Dinaciclib
Dinaciclib is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM in cell-free assays, respectively. It also blocks thymidine (dThd) DNA incorporation. Dinaciclib induces apoptosis through the activation of caspases 8 and 9. Phase 3.
| Trivial name | SCH727965, PS-095760 |
| Catalog Number | S2768 |
| Molecular Formula | C26H27F4N3O7 |
| CAS# | 779353-01-4 |
| Inchi | InChI=1S/C26H27F4N3O7/c1-12(31-24(38)25(39)32-16-8-6-5-7-13(16)26(2,3)4)23(37)33-17(10-19(35)36)18(34)11-40-22-20(29)14(27)9-15(28)21(22)30/h5-9,12,17H,10-11H2,1-4H3,(H,31,38)(H,32,39)(H,33,37)(H,35,3 6)/t12-,17-/m0/s1 |
| Inchi Key | SCVHJVCATBPIHN-SJCJKPOMSA-N |
| SMILES | CC(C(=O)NC(CC(=O)O)C(=O)COC1=C(C(=CC(=C1F)F)F)F)NC(=O)C(=O)NC2=CC=CC=C2C(C)(C)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/dinaciclib-sch727965.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Dinaciclib(SCH-727965)-chemical-structure-s2768.gif |