Wortmannin
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM in a cell-free assay, with little selectivity within the PI3K family. Wortmannin blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM in cell-free assays. Wortmannin also inhibits PLK1 activity.
| Trivial name | KY 12420, SL-2052, BRN 0067676, NSC 627609 |
| Catalog Number | S2758 |
| Molecular Formula | C29H27F5N2O6S |
| CAS# | 19545-26-7 |
| Inchi | InChI=1S/C29H27F5N2O6S/c1-35(43(41,42)28-26(33)24(31)23(30)25(32)27(28)34)15-22(38)36(19-11-12-20(29(39)40)21(37)13-19)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h7-13,17,37H,2-6,14-15H2,1H3,(H,39,40) |
| Inchi Key | WNVSFFVDMUSXSX-UHFFFAOYSA-N |
| SMILES | CN(CC(=O)N(CC1=CC=C(C=C1)C2CCCCC2)C3=CC(=C(C=C3)C(=O)O)O)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F |
| Size | 20mg |
| Supplier Page | http://www.selleckchem.com/products/wortmannin.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Wortmannin-chemical-structure-s2758.gif |