Milciclib
Milciclib is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7, it’s also an inhibitor of TRKA with IC50 of 53nM. Milciclib (PHA-848125) induces cell death through autophagy. Phase 2.
| Trivial name | PHA-848125 |
| Catalog Number | S2751 |
| Molecular Formula | C25H32N8O |
| CAS# | 802539-81-7 |
| Inchi | InChI=1S/C25H32N8O/c1-25(2)14-16-15-27-24(29-20(16)22-19(25)21(23(34)26-3)30-32(22)5)28-17-6-8-18(9-7-17)33-12-10-31(4)11-13-33/h6-9,15H,10-14H2,1-5H3,(H,26,34)(H,27,28,29) |
| Inchi Key | RXZMYLDMFYNEIM-UHFFFAOYSA-N |
| SMILES | CC1(CC2=CN=C(N=C2C3=C1C(=NN3C)C(=O)NC)NC4=CC=C(C=C4)N5CCN(CC5)C)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/pha-848125.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PHA-848125-chemical-structure-s2751.gif |