AMG-458
AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.
| Trivial name | N/A |
| Catalog Number | S2747 |
| Molecular Formula | C30H29N5O5 |
| CAS# | 913376-83-7 |
| Inchi | InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36) |
| Inchi Key | GLBZSOQDAOLMGC-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=NC=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/amg458.html |
| Additional Information | https://file.selleck.cn/downloads/struct/AMG-458-chemical-structure-s2747.gif |