AZ 628
AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM in cell-free assays, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc. AZ628 induces apoptosis.
| Trivial name | N/A |
| Catalog Number | S2746 |
| Molecular Formula | C27H25N5O2 |
| CAS# | 878739-06-1 |
| Inchi | InChI=1S/C27H25N5O2/c1-17-8-9-21(31-25(33)18-6-5-7-19(12-18)27(2,3)15-28)14-24(17)30-20-10-11-23-22(13-20)26(34)32(4)16-29-23/h5-14,16,30H,1-4H3,(H,31,33) |
| Inchi Key | ZGBGPEDJXCYQPH-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/az628.html |
| Additional Information | https://file.selleck.cn/downloads/struct/AZ628-chemical-structure-s2746.gif |