PF-04691502
PF-04691502 (PF4691502) is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM in cell-free assays, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK. PF-04691502 induces apoptosis. Phase 2.
| Trivial name | PF4691502 |
| Catalog Number | S2743 |
| Molecular Formula | C12H14N2O2 |
| CAS# | 1013101-36-4 |
| Inchi | InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m1/s1 |
| Inchi Key | ZADWXFSZEAPBJS-SNVBAGLBSA-N |
| SMILES | CN1C=C(C2=CC=CC=C21)CC(C(=O)O)N |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/pf-04691502.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PF-04691502-chemical-structure-s2743.gif |