PHA-767491 HCl
PHA-767491 (CAY10572, NMS 1116354) HCl is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM in cell-free assays, respectively.It displays ~20-fold selectivity against CDK1/2 and GSK3-β, 50-fold selectivity against MK2 and CDK5, 100-fold selectivity against PLK1 and CHK2.
| Trivial name | CAY10572, NMS 1116354 |
| Catalog Number | S2742 |
| Molecular Formula | C29H44N8O3 |
| CAS# | 942425-68-5 |
| Inchi | InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34) |
| Inchi Key | GYQYAJJFPNQOOW-UHFFFAOYSA-N |
| SMILES | CCC1=C(N=C(C(=N1)C(=O)N)NC2=CC(=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC)NC5CCOCC5 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/pha-767491-hcl.html |
| Additional Information | https://file.selleck.cn/downloads/struct/pha-767491-chemical-structure-s2742.gif |