PHA-767491 HCl
PHA-767491 (CAY10572, NMS 1116354) HCl is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM in cell-free assays, respectively.It displays ~20-fold selectivity against CDK1/2 and GSK3-β, 50-fold selectivity against MK2 and CDK5, 100-fold selectivity against PLK1 and CHK2.
| Trivial name | CAY10572, NMS 1116354 |
| Catalog Number | S2742 |
| Molecular Formula | C12H11N3O.HCl |
| CAS# | 942425-68-5 |
| Inchi | InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16) |
| Inchi Key | DKXHSOUZPMHNIZ-UHFFFAOYSA-N |
| SMILES | C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3.Cl |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/pha-767491.html |
| Additional Information | https://file.selleck.cn/downloads/struct/pha-767491-chemical-structure-s2742.gif |