Crenolanib
Crenolanib is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Crenolanib helps to induce mitophagy.
| Trivial name | CP-868596, ARO 002 |
| Catalog Number | S2730 |
| Molecular Formula | C22H21N3O3S |
| CAS# | 670220-88-9 |
| Inchi | InChI=1S/C22H21N3O3S/c26-20(25-17-10-5-6-12-23-21(17)27)15-8-2-3-9-16(15)24-22(28)19-13-14-7-1-4-11-18(14)29-19/h1-4,7-9,11,13,17H,5-6,10,12H2,(H,23,27)(H,24,28)(H,25,26) |
| Inchi Key | TUSCYCAIGRVBMD-UHFFFAOYSA-N |
| SMILES | C1CCNC(=O)C(C1)NC(=O)C2=CC=CC=C2NC(=O)C3=CC4=CC=CC=C4S3 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/crenolanib-cp-868596.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Crenolanib-chemical-structure-s2730.gif |