Crenolanib
Crenolanib is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM in CHO cells, also potently inhibits FLT3, sensitive to D842V mutation not V561D mutation, >100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src. Crenolanib helps to induce mitophagy.
| Trivial name | CP-868596, ARO 002 |
| Catalog Number | S2730 |
| Molecular Formula | C27H24FN7O3 |
| CAS# | 670220-88-9 |
| Inchi | InChI=1S/C27H24FN7O3/c1-27(2,3)21-14-22(35(34-21)16-7-5-4-6-8-16)32-26(37)31-19-10-9-17(13-18(19)28)38-20-11-12-29-25-24(20)30-15-23(36)33-25/h4-15H,1-3H3,(H,29,33,36)(H2,31,32,37) |
| Inchi Key | KYYKGSDLXXKQCR-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=NN(C(=C1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C(=NC=C3)NC(=O)C=N4)F)C5=CC=CC=C5 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/crenolanib-cp-868596.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Crenolanib-chemical-structure-s2730.gif |