AMG-900
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.
| Trivial name | N/A |
| Catalog Number | S2719 |
| Molecular Formula | C28H21N7OS |
| CAS# | 945595-80-2 |
| Inchi | InChI=1S/C28H21N7OS/c1-17-15-24(37-16-17)25-20-5-2-3-6-21(20)26(35-34-25)32-18-8-10-19(11-9-18)36-27-22(7-4-13-30-27)23-12-14-31-28(29)33-23/h2-16H,1H3,(H,32,35)(H2,29,31,33) |
| Inchi Key | IVUGFMLRJOCGAS-UHFFFAOYSA-N |
| SMILES | CC1=CSC(=C1)C2=NN=C(C3=CC=CC=C32)NC4=CC=C(C=C4)OC5=C(C=CC=N5)C6=NC(=NC=C6)N |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/amg-900.html |
| Additional Information | https://file.selleck.cn/downloads/struct/amg-900-chemical-structure-s2719.gif |