Geldanamycin
Geldanamycin is a natural existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host’s inflammatory responses.
| Trivial name | NSC 122750 |
| Catalog Number | S2713 |
| Molecular Formula | C20H22N4O3S |
| CAS# | 30562-34-6 |
| Inchi | InChI=1S/C20H22N4O3S/c1-21-19(26)16-10-13(8-9-22-16)27-12-6-7-15-18(11-12)28-20(24-15)23-14-4-2-3-5-17(14)25/h6-11,14,17,25H,2-5H2,1H3,(H,21,26)(H,23,24)/t14-,17-/m1/s1 |
| Inchi Key | ADZBMFGQQWPHMJ-RHSMWYFYSA-N |
| SMILES | CNC(=O)C1=NC=CC(=C1)OC2=CC3=C(C=C2)N=C(S3)NC4CCCCC4O |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/geldanamycin.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Geldanamycin-chemical-structure-s2713.gif |