TG101209
TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET (c-RET) with IC50 of 25 nM and 17 nM in cell-free assays, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations.
| Trivial name | N/A |
| Catalog Number | S2692 |
| Molecular Formula | C19H19N5O |
| CAS# | 936091-14-4 |
| Inchi | InChI=1S/C19H19N5O/c1-13-6-4-5-7-17(13)23-22-15-8-9-16(14(2)12-15)21-19(25)18-10-11-20-24(18)3/h4-12H,1-3H3,(H,21,25)/b23-22+ |
| Inchi Key | LKTNEXPODAWWFM-GHVJWSGMSA-N |
| SMILES | CC1=CC=CC=C1N=NC2=CC(=C(C=C2)NC(=O)C3=CC=NN3C)C |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/tg101209.html |
| Additional Information | https://file.selleck.cn/downloads/struct/TG101209-chemical-structure-s2692.gif |