Flavopiridol (Alvocidib) HCl

Flavopiridol (Alvocidib) HCl competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2.

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Trivial name	NSC 649890, L86-8275, HMR-1275, DSP-2033
Catalog Number	S2679
Molecular Formula	C24H32Cl4N6OS
CAS#	131740-09-5
Inchi	InChI=1S/C24H29ClN6OS.3ClH/c1-30-10-12-31(13-11-30)9-3-8-26-24-27-15-19(25)22(29-24)21-14-18-17(4-2-5-20(18)33-21)23(32)28-16-6-7-16;;;/h2,4-5,14-16H,3,6-13H2,1H3,(H,28,32)(H,26,27,29);3*1H
Inchi Key	IEXCRLAGBWKVPW-UHFFFAOYSA-N
SMILES	CN1CCN(CC1)CCCNC2=NC=C(C(=N2)C3=CC4=C(C=CC=C4S3)C(=O)NC5CC5)Cl.Cl.Cl.Cl
Size	10mg
Supplier Page	http://www.selleckchem.com/products/flavopiridol-hydrochloride.html
Additional Information	https://file.selleck.cn/downloads/struct/Flavopiridol-hydrochloride-chemical-structure-S2679.gif