Trametinib (GSK1120212)
Trametinib (GSK1120212, JTP-74057) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Trametinib activates autophagy and induces apoptosis.
| Trivial name | JTP-74057 |
| Catalog Number | S2673 |
| Molecular Formula | C25H19N5S |
| CAS# | 871700-17-3 |
| SMILES | CC1=NC(=CC=C1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/gsk1120212-jtp-74057.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GSK1120212-JTP-74057-chemical-structure-s2673.gif |